| 01/02/00 | 00-01 | The Dr. Demento Show #00-01 - January 2, 2000
Topic: Things that probably won't change much in the new millennium | | |
| 01/09/00 | 00-02 | The Dr. Demento Show #00-02 - January 9, 2000
Topic: Demented doo-wop | | |
| 01/16/00 | 00-03 | The Dr. Demento Show #00-03 - January 16, 2000
Topic: Demented diet songs | | |
| 01/23/00 | 00-04 | The Dr. Demento Show #00-04 - January 23, 2000
Topic: Myself - songs with the word "I" in the title | | |
| 01/30/00 | 00-05 | The Dr. Demento Show #00-05 - January 30, 2000
Topic: Hawaii | | |
| 02/06/00 | 00-06 | The Dr. Demento Show #00-06 - February 6, 2000
Topic: comedy dialogues and duets | | |
| 02/13/00 | 00-07 | The Dr. Demento Show #00-07 - February 13, 2000
Topic: demented love songs | | |
| 02/20/00 | 00-08 | The Dr. Demento Show #00-08 - February 20, 2000
Topic: the side effects of love | | |
| 02/27/00 | 00-09 | The Dr. Demento Show #00-09 - February 27, 2000
Topic: Dementia 2000 (a new Dr. Demento double-CD coming out February 29th from Rhino) | | |
| 03/05/00 | 00-10 | The Dr. Demento Show #00-10 - March 5, 2000
Topic: doctor songs and military dementia | | |
| 03/12/00 | 00-11 | The Dr. Demento Show #00-11 - March 12, 2000
Topic: St. Patrick's Day (green) | | |
| 03/19/00 | 00-12 | The Dr. Demento Show #00-12 - March 19, 2000
Topic: the vernal equinox (songs about spring) | | |
| 03/26/00 | 00-13 | The Dr. Demento Show #00-13 - March 26, 2000
Topic: Comedians of Canada | | |
| 04/02/00 | 00-14 | The Dr. Demento Show #00-14 - April 2, 2000
Topic: food | | |
| 04/09/00 | 00-15 | The Dr. Demento Show #00-15 - April 9, 2000
Topic: stupidity |  | |
| 04/16/00 | 00-16 | The Dr. Demento Show #00-16 - April 16, 2000
Topic: Earth Day | | |
| 04/23/00 | 00-17 | The Dr. Demento Show #00-17 - April 23, 2000
Topic: tobacco tunes (pro and con) | | |
| 04/30/00 | 00-18 | The Dr. Demento Show #00-18 - April 30, 2000
Topic: cow songs | | |
| 05/07/00 | 00-19 | The Dr. Demento Show #00-19 - May 7, 2000
Topic: winners of recent funny song contest | | |
| 05/14/00 | 00-20 | The Dr. Demento Show #00-20 - May 14, 2000
Topic: television | | |
| 05/21/00 | 00-21 | The Dr. Demento Show #00-21 - May 21, 2000
Topic: science fictional dementia | | |
| 05/28/00 | 00-22 | The Dr. Demento Show #00-22 - May 28, 2000
Topic: Star Trek | | |
| 06/04/00 | 00-23 | The Dr. Demento Show #00-23 - June 4, 2000
Topic: squirrels & hamsters & gerbils & chipmunks & mice & rats (rodents rule!); [also, the telephone] | | |
| 06/11/00 | 00-24 | The Dr. Demento Show #00-24 - June 11, 2000
Topic: cockroaches | | |
| 06/18/00 | 00-25 | The Dr. Demento Show #00-25 - June 18, 2000
Topic: Father's Day; Let's do it! | | |
| 06/25/00 | 00-26 | The Dr. Demento Show #00-26 - June 25, 2000
Topic: airplanes and aviation | | |
| 07/02/00 | 00-27 | The Dr. Demento Show #00-27 - July 2, 2000
Topic: Fourth Of July (all-American) | | |
| 07/09/00 | 00-28 | The Dr. Demento Show #00-28 - July 9, 2000
Topic: demented identity crisis (14 different songs all with the words "I Am" or "I'm") | | |
| 07/16/00 | 00-29 | The Dr. Demento Show #00-29 - July 16, 2000
Topic: Christmas In July | | |
| 07/23/00 | 00-30 | The Dr. Demento Show #00-30 - July 23, 2000
Topic: freaks; a tribute to the late Cub Koda | | |
| 07/30/00 | 00-31 | The Dr. Demento Show #00-31 - July 30, 2000
Topic: big | | |
| 08/06/00 | 00-32 | The Dr. Demento Show #00-32 - August 6, 2000
Topic: little things, small things, even tiny things | | |
| 08/13/00 | 00-33 | The Dr. Demento Show #00-33 - August 13, 2000
Topic: body parts | | |
| 08/20/00 | 00-34 | The Dr. Demento Show #00-34 - August 20, 2000
Topic: the dog days of summer | | |
| 08/27/00 | 00-35 | The Dr. Demento Show #00-35 - August 27, 2000
Topic: kitty ditties | | |
| 09/03/00 | 00-36 | The Dr. Demento Show #00-36 - September 3, 2000
Topic: the demented side of working | | |
| 09/10/00 | 00-37 | The Dr. Demento Show #00-37 - September 10, 2000
Topic: 20th anniversary of "Weird Al" Yankovic's live debut performance of "Another One Rides The Bus"; words | | |
| 09/17/00 | 00-38 | The Dr. Demento Show #00-38 - September 17, 2000
Topic: caffeine | | |
| 09/24/00 | 00-39 | The Dr. Demento Show #00-39 - September 24, 2000
Topic: MY songs (songs with the word "my" in the title) | | |
| 10/01/00 | 00-40 | The Dr. Demento Show #00-40 - October 1, 2000
Topic: YOUR songs | | |
| 10/08/00 | 00-41 | The Dr. Demento Show #00-41 - October 8, 2000
Topic: medical dementia | | |
| 10/15/00 | 00-42 | The Dr. Demento Show #00-42 - October 15, 2000
Topic: something we only salute every four years | | |
| 10/22/00 | 00-43 | The Dr. Demento Show #00-43 - October 22, 2000
Topic: Halloween part 1/2 | | |
| 10/29/00 | 00-44 | The Dr. Demento Show #00-44 - October 29, 2000
Topic: Halloween part 2/2 | | |
| 11/05/00 | 00-45 | The Dr. Demento Show #00-45 - November 5, 2000
Topic: hunting season (also a song or two for voting season) | | |
| 11/12/00 | 00-46 | The Dr. Demento Show #00-46 - November 12, 2000
Topic: demented do's and don'ts | | |
| 11/19/00 | 00-47 | The Dr. Demento Show #00-47 - November 19, 2000
Topic: musical turkeys (f/ the return of the Audio Torture Chamber) | | |
| 11/26/00 | 00-48 | The Dr. Demento Show #00-48 - November 26, 2000
Topic: demented places | | |
| 12/03/00 | 00-49 | The Dr. Demento Show #00-49 - December 3, 2000
Topic: Christmas part 1/4 | | |
| 12/10/00 | 00-50 | The Dr. Demento Show #00-50 - December 10, 2000
Topic: Christmas part 2/4 | | |
| 12/17/00 | 00-51 | The Dr. Demento Show #00-51 - December 17, 2000
Topic: Christmas part 3/4 | | |
| 12/24/00 | 00-52 | The Dr. Demento Show #00-52 - December 24, 2000
Topic: Christmas part 4/4 | | |
| 12/31/00 | 00-53 | The Dr. Demento Show #00-53 - December 31, 2000
Topic: The Funny 25 | | |